This article has no abstract; the first 100 words appear below.
Beck et al. define an adult-onset inflammatory disorder that unites multiple clinical conditions with previously different diagnoses or with no diagnosis at all; their findings are now reported in the Journal.1 The VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is defined by genotype, not by clinical phenotype. We agree with the authors that the names of disorders should be based on the responsible gene or pathway. Gene-based nosology best complements the discovery and deployment of genotype-targeted treatments for both inherited and noninherited forms of disease.2 Beck et al. found that myeloid cells in each patient with the VEXAS syndrome . . .